Multiple beneficial health effects of natural alkylglycerols from shark liver oil.

Abstract : Alkylglycerols (alkyl-Gro) are ether lipids abundant in the liver of some elasmobranch fish species such as ratfishes and some sharks. Shark liver oil from Centrophorus squamosus (SLO), or alkyl-Gro mix from this source, have several in vivo biological activities including stimulation of hematopoiesis and immunological defences, sperm quality improvement, or anti-tumor and anti-metastasis activities. Several mechanisms are suggested for these multiple activities, resulting from incorporation of alkyl-Gro into membrane phospholipids, and lipid signaling interactions. Natural alkyl-Gro mix from SLO contains several alkyl-Gro, varying by chain length and unsaturation. Six prominent constituents of natural alkyl-Gro mix, namely 12:0, 14:0, 16:0, 18:0, 16:1 n-7, and 18:1 n-9 alkyl-Gro, were synthesized and tested for anti-tumor and anti-metastatic activities on a model of grafted tumor in mice (3LL cells). 16:1 and 18:1 alkyl-Gro showed strong activity in reducing lung metastasis number, while saturated alkyl- Gro had weaker (16:0) or no (12:0, 14:0, 18:0) effect. Multiple compounds and mechanisms are probably involved in the multiple activities of natural alkyl-Gro.
Type de document :
Article dans une revue
Marine drugs, MDPI, 2010, 8 (7), pp.2175-84. 〈10.3390/md8072175〉
Liste complète des métadonnées

Littérature citée [41 références]  Voir  Masquer  Télécharger
Contributeur : Céline Martel <>
Soumis le : mardi 5 mars 2013 - 16:26:43
Dernière modification le : jeudi 21 juin 2018 - 01:11:43
Document(s) archivé(s) le : vendredi 31 mars 2017 - 12:34:12


Fichiers éditeurs autorisés sur une archive ouverte



Anne-Laure Deniau, Paul Mosset, Frédérique Pédrono, Romain Mitre, Damien Le Bot, et al.. Multiple beneficial health effects of natural alkylglycerols from shark liver oil.. Marine drugs, MDPI, 2010, 8 (7), pp.2175-84. 〈10.3390/md8072175〉. 〈hal-00729584〉



Consultations de la notice


Téléchargements de fichiers