Cell junction disruption after 36h milk accumulation was associated with changes in mammary secretory tissue activity ans dynamics in lactating dairy goats

H. Ben Chedly P. Lacasse Pierre-Guy Marnet 1 S. Wiart-Letort L. Finot M. Boutinaud
1 PL - Production du lait
Abstract : Milk stasis in the mammary gland is a situation that induces a reduction in milk yield and a change in its composition. Theses changes could be related to a decrease in the number and/or activity of secretory cells. Previous observations showed that a disruption of cell junctions is one of the early phenomena accompanying milk accumulation in the mammary gland. The aim of the present study was to investigate the local effect of 36 h milk accumulation on mammary cells activity, apoptosis and proliferation. We also studied the expression of cell junction proteins after 36 h of milk stasis. We observed a decrease in the quantity of milk produced after 36 h of milk stasis in goat. Lower milk lactose and protein yields were also observed, which was associated with a decrease in the transcripts of genes involved in synthesis of these constituents, such as alpha-lactalbumin and kappa-casein. Mammary gland apoptosis was more intensive than mammary cell proliferation after 36 h of milk accumulation. All these changes were associated with an up-regulation of E-cadherin protein and increase of its transcripts levels. It could suggest that these adjustments are made in order to limit losses of secretory cell number and activity.
Keywords : apoptosis milk stasis proliferation once-daily milking epithelial-cells e-cadherin short communication alpha-lactalbumin gland involution tight junctions expression genes
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Article dans une revue
Journal of Physiology and Pharmacology, Krakow Polish Physiological Society, 2009, 60, pp.105-111
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https://hal-agrocampus-ouest.archives-ouvertes.fr/hal-00730137
Contributeur : Céline Martel <>
Soumis le : vendredi 7 septembre 2012 - 16:11:18
Dernière modification le : mercredi 21 mars 2018 - 16:08:10

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H. Ben Chedly, P. Lacasse, Pierre-Guy Marnet, S. Wiart-Letort, L. Finot, et al.. Cell junction disruption after 36h milk accumulation was associated with changes in mammary secretory tissue activity ans dynamics in lactating dairy goats. Journal of Physiology and Pharmacology, Krakow Polish Physiological Society, 2009, 60, pp.105-111. 〈hal-00730137〉

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