Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations

Abstract : Fungi are of primary ecological, biotechnological and economic importance. Many fundamental biological processes that are shared by animals and fungi are studied in fungi due to their experimental tractability. Many fungi are pathogens or mutualists and are model systems to analyse effector genes and their mechanisms of diversification. In this study, we report the genome sequence of the phytopathogenic ascomycete Leptosphaeria maculans and characterize its repertoire of protein effectors. The L. maculans genome has an unusual bipartite structure with alternating distinct guanine and cytosine-equilibrated and adenine and thymine (AT)-rich blocks of homogenous nucleotide composition. The AT-rich blocks comprise one-third of the genome and contain effector genes and families of transposable elements, both of which are affected by repeat-induced point mutation, a fungal-specific genome defence mechanism. This genomic environment for effectors promotes rapid sequence diversification and underpins the evolutionary potential of the fungus to adapt rapidly to novel host-derived constraints.
Document type :
Journal articles
Complete list of metadatas

Cited literature [77 references]  Display  Hide  Download

https://hal-agrocampus-ouest.archives-ouvertes.fr/hal-00841751
Contributor : Catherine Cliquet <>
Submitted on : Monday, September 2, 2019 - 4:25:31 PM
Last modification on : Thursday, October 10, 2019 - 2:26:03 PM

File

ncomms1189.pdf
Publisher files allowed on an open archive

Identifiers

Citation

T. Rouxel, J. Grandaubert, Jk. Hane, C. Hoede, Angela P. van de Wouw, et al.. Effector diversification within compartments of the Leptosphaeria maculans genome affected by Repeat-Induced Point mutations. Nature Communications, Nature Publishing Group, 2011, 2, pp.202. ⟨10.1038/ncomms1189⟩. ⟨hal-00841751⟩

Share

Metrics

Record views

195

Files downloads

18