Molecular Cloning and Functional Characterization of Rat ??-6 Fatty Acid Desaturase, Biochemical and Biophysical Research Communications, vol.255, issue.3, pp.575-579, 1999. ,
DOI : 10.1006/bbrc.1999.0235
Physiological roles revealed by ghrelin and ghrelin receptor deficient mice, Peptides, vol.32, issue.11, pp.2229-2235, 2011. ,
DOI : 10.1016/j.peptides.2011.07.003
Fatty Acid Composition of Caprine Milk: Major, Branched-Chain, and Trans Fatty Acids, Journal of Dairy Science, vol.82, issue.5, pp.878-884, 1999. ,
DOI : 10.3168/jds.S0022-0302(99)75306-3
Effect of octanoic acid-rich formula on plasma ghrelin levels in cachectic patients with chronic respiratory disease, Nutrition Journal, vol.175, issue.1, p.25, 2009. ,
DOI : 10.1164/rccm.200701-067OC
Myristic acid increases the activity of dihydroceramide ??4-desaturase 1 through its N-terminal myristoylation, Biochimie, vol.89, issue.12, pp.1553-1561, 2007. ,
DOI : 10.1016/j.biochi.2007.07.001
Acide myristique??: nouvelles fonctions de r??gulation et de signalisation, m??decine/sciences, vol.25, issue.1, pp.57-63, 2009. ,
DOI : 10.1051/medsci/200925157
N-Myristoylation targets dihydroceramide ??4-desaturase 1 to mitochondria: Partial involvement in the apoptotic effect of myristic acid, Biochimie, vol.91, issue.11-12, pp.1411-1419, 2009. ,
DOI : 10.1016/j.biochi.2009.07.014
URL : https://hal.archives-ouvertes.fr/hal-00730029
Selectivity of ceramide-mediated biology. Lack of activity of erythro-dihydroceramide, J. Biol. Chem, vol.268, pp.26226-26232, 1993. ,
Mechanistic effects of protein palmitoylation and the cellular consequences thereof, Chemistry and Physics of Lipids, vol.180, pp.44-52, 2014. ,
DOI : 10.1016/j.chemphyslip.2014.02.001
A role for N-myristoylation in protein targeting: NADH-cytochrome b5 reductase requires myristic acid for association with outer mitochondrial but not ER membranes, The Journal of Cell Biology, vol.135, issue.6, pp.1501-1513, 1996. ,
DOI : 10.1083/jcb.135.6.1501
Regulation of G proteins by covalent modification, Oncogene, vol.20, issue.13, pp.1643-1652, 2001. ,
DOI : 10.1038/sj.onc.1204185
Ghrelin: a journey from GH secretagogue to regulator of metabolism, Transl. Gastrointest. Cancer, vol.4, pp.14-27, 2014. ,
Cloning, Expression, and Nutritional Regulation of the Mammalian ??-6 Desaturase, Journal of Biological Chemistry, vol.274, issue.1, pp.471-477, 1999. ,
DOI : 10.1074/jbc.274.1.471
Lipolysis and absorption of fat in the rat stomach, Gastroenterology, vol.56, pp.214-222, 1969. ,
N-myristoylation determines dual targeting of mammalian NADH-cytochrome b(5) reductase to ER and mitochondrial outer membranes by a mechanism of kinetic partitioning, The Journal of Cell Biology, vol.268, issue.5, pp.735-745, 2005. ,
DOI : 10.1002/pro.5560021003
The same rat ??6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis, Biochemical Journal, vol.364, issue.1, pp.49-55, 2002. ,
DOI : 10.1042/bj3640049
-Acyltransferase Reveals Chemical Determinants of Ghrelin Selectivity and Acyl Group Recognition, Biochemistry, vol.54, issue.4, pp.1100-1110, 2015. ,
DOI : 10.1021/bi5010359
URL : https://hal.archives-ouvertes.fr/in2p3-00011871
Des-Acyl Ghrelin: A Metabolically Active Peptide, Endocr. Dev, vol.25, pp.112-121, 2013. ,
DOI : 10.1159/000346059
Structure and Physiological Actions of Ghrelin, Scientifica, vol.26, issue.8, supplement, p.518909, 2013. ,
DOI : 10.1016/j.bone.2007.05.006
Two N-Myristoyltransferase Isozymes Play Unique Roles in Protein Myristoylation, Proliferation, and Apoptosis, Molecular Cancer Research, vol.3, issue.8, pp.463-476, 2005. ,
DOI : 10.1158/1541-7786.MCR-05-0037
Myristic acid auxotrophy caused by mutation of S. cerevisiae myristoyl- CoA:protein N-myristoyltransferase, The Journal of Cell Biology, vol.113, issue.6, pp.1313-1330, 1991. ,
DOI : 10.1083/jcb.113.6.1313
Mutations of human myristoyl-CoA:protein N-myristoyltransferase cause temperature-sensitive myristic acid auxotrophy in Saccharomyces cerevisiae., Proc. Natl. Acad. Sci. USA, pp.4129-4133, 1992. ,
DOI : 10.1073/pnas.89.9.4129
Myristic Acid Increases Dihydroceramide ??4-Desaturase 1 (DES1) Activity in Cultured Rat Hepatocytes, Myristic acid increases dihydroceramide Delta4-desaturase 1 (DES1) activity in cultured rat hepatocytes, pp.117-128, 2012. ,
DOI : 10.1007/s11745-011-3638-x
L???acylation des prot??ines??: une fonction cellulaire importante des acides gras satur??s, Nutrition Clinique et M??tabolisme, vol.27, issue.1, pp.10-19, 2013. ,
DOI : 10.1016/j.nupar.2012.11.001
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling, Biochemical Journal, vol.323, issue.1, pp.1-12, 1997. ,
DOI : 10.1042/bj3230001
Studies on fat digestion, absorption, and transport in the suckling rat. I. Fatty acid composition and concentrations of major lipid components, J. Lipid Res, vol.22, pp.668-674, 1981. ,
Ingestion of medium chain fatty acids by lactating dairy cows increases concentrations of plasma ghrelin, Domestic Animal Endocrinology, vol.45, issue.4, pp.216-223, 2013. ,
DOI : 10.1016/j.domaniend.2013.09.005
Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species. Role of mitochondrial glutathione, J. Biol. Chem, vol.272, pp.11369-11377, 1997. ,
A Second Mammalian N-Myristoyltransferase, Journal of Biological Chemistry, vol.273, issue.12, pp.6595-6598, 1998. ,
DOI : 10.1074/jbc.273.12.6595
The ghrelin activating enzyme ghrelin-O-acyltransferase (GOAT) is present in human plasma and expressed dependent on body mass index, Peptides, vol.43, pp.13-19, 2013. ,
DOI : 10.1016/j.peptides.2013.02.011
G protein-coupled receptor 120 signaling regulates ghrelin secretion in vivo and in vitro, AJP: Endocrinology and Metabolism, vol.306, issue.1, pp.28-35, 2014. ,
DOI : 10.1152/ajpendo.00306.2013
DHHC palmitoyl transferases: substrate interactions and (patho)physiology, Trends in Biochemical Sciences, vol.36, issue.5, pp.245-253, 2011. ,
DOI : 10.1016/j.tibs.2011.01.003
Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide, Journal of Biological Chemistry, vol.272, issue.39, pp.24154-24158, 1997. ,
DOI : 10.1074/jbc.272.39.24154
Distinct roles of endoplasmic reticulum cytochrome b5 and fused cytochrome b5-like domain for rat ??6-desaturase activity, The Journal of Lipid Research, vol.45, issue.1, pp.32-40, 2004. ,
DOI : 10.1194/jlr.M300339-JLR200
Ghrelin octanoylation mediated by an orphan lipid transferase, Proc. Natl. Acad, 2008. ,
DOI : 10.1073/pnas.0800708105
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release, Science, vol.273, issue.5277, pp.974-977, 1996. ,
DOI : 10.1126/science.273.5277.974
Myristic acid increases ??6-desaturase activity in cultured rat hepatocytes, Reproduction Nutrition Development, vol.44, issue.2, pp.131-140, 2004. ,
DOI : 10.1051/rnd:2004020
URL : https://hal.archives-ouvertes.fr/hal-00900482
Sensing of Fatty Acids for Octanoylation of Ghrelin Involves a Gustatory G-Protein, PLoS ONE, vol.414, issue.6, p.40168, 2012. ,
DOI : 10.1371/journal.pone.0040168.g007
The lipids in human milk, Progress in Lipid Research, vol.35, issue.1, pp.53-92, 1996. ,
DOI : 10.1016/0163-7827(95)00010-0
Lipids of Bovine and Human Milks: A Comparison, Journal of Dairy Science, vol.73, issue.2, pp.223-240, 1990. ,
DOI : 10.3168/jds.S0022-0302(90)78666-3
Genetic and Biochemical Studies of Protein N-Myristoylation, Annual Review of Biochemistry, vol.63, issue.1, pp.869-914, 1994. ,
DOI : 10.1146/annurev.bi.63.070194.004253
Saccharomyces cerevisiae contains four fatty acid activation (FAA) genes: an assessment of their role in regulating protein N- myristoylation and cellular lipid metabolism, The Journal of Cell Biology, vol.127, issue.3, pp.751-62, 1994. ,
DOI : 10.1083/jcb.127.3.751
Chronic Central Infusion of Ghrelin Increases Hypothalamic Neuropeptide Y and Agouti-Related Protein mRNA Levels and Body Weight in Rats, Diabetes, vol.50, issue.11, pp.2438-2443, 2001. ,
DOI : 10.2337/diabetes.50.11.2438
Effects of fats and fatty acids on blood lipids in humans: an overview. Am, J. Clin. Nutr, vol.60, pp.1017-1022, 1994. ,
Ghrelin is a growth-hormone-releasing acylated peptide from stomach, Nature, vol.402, issue.6762, pp.656-660, 1999. ,
DOI : 10.1038/45230
Gastric digestion modifies absorption of butterfat into lymph chylomicrons in rats, J. Nutr, vol.128, pp.2403-2410, 1998. ,
Nouvelle approche pour les recommandations nutritionnelles en lipides, Ol??agineux, Corps gras, Lipides, vol.20, issue.2, pp.75-78, 2013. ,
DOI : 10.1051/ocl.2013.0502
Specific roles of saturated fatty acids: Beyond epidemiological data, European Journal of Lipid Science and Technology, vol.102, issue.10, pp.1489-1499, 2015. ,
DOI : 10.1002/ejlt.201400514
URL : https://hal.archives-ouvertes.fr/hal-01409007
Short Chain Saturated Fatty Acids Decrease Circulating Cholesterol and Increase Tissue PUFA Content in the Rat, Lipids, vol.60, issue.11, pp.975-86, 2010. ,
DOI : 10.1007/s11745-010-3481-5
URL : https://hal.archives-ouvertes.fr/hal-00729618
Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat, PLOS ONE, vol.93, issue.Suppl 1, p.133600, 2015. ,
DOI : 10.1371/journal.pone.0133600.s008
Revisiting the metabolism and physiological functions of caprylic acid (C8:0) with special focus on ghrelin octanoylation, Biochimie, vol.120, 2015. ,
DOI : 10.1016/j.biochi.2015.08.002
The expression of ghrelin O-acyltransferase (GOAT) in human tissues, Endocrine Journal, vol.58, issue.8, 2011. ,
DOI : 10.1507/endocrj.K11E-117
Post-translational myristoylation: Fat matters in cellular life and death, Biochimie, vol.93, issue.1, pp.18-31, 2011. ,
DOI : 10.1016/j.biochi.2010.10.018
MYRbase: analysis of genome-wide glycine myristoylation enlarges the functional spectrum of eukaryotic myristoylated proteins, 2004. ,
Protein palmitoylation by a family of DHHC protein S-acyltransferases, The Journal of Lipid Research, vol.47, issue.6, 2006. ,
DOI : 10.1194/jlr.R600007-JLR200
Identification of the human sphingolipid C4-hydroxylase, hDES2, and its up-regulation during keratinocyte differentiation, FEBS Letters, vol.22, issue.1-3, pp.93-97, 2004. ,
DOI : 10.1016/S0014-5793(04)00274-1
Ingested Medium-Chain Fatty Acids Are Directly Utilized for the Acyl Modification of Ghrelin, Endocrinology, vol.146, issue.5, pp.2255-2264, 2005. ,
DOI : 10.1210/en.2004-0695
Developmental Changes in the Pattern of Ghrelin???s Acyl Modification and the Levels of Acyl-Modified Ghrelins in Murine Stomach, Endocrinology, vol.146, issue.6, pp.2709-2715, 2005. ,
DOI : 10.1210/en.2004-0645
Changes in subcellular distribution of n-octanoyl or n-decanoyl ghrelin in ghrelinproducing cells, Front. Endocrinol, vol.4, p.84, 2013. ,
DES2 protein is responsible for phytoceramide biosynthesis in the mouse small intestine, Biochemical Journal, vol.379, issue.3, pp.687-695, 2004. ,
DOI : 10.1042/bj20031425
Identification of the NH2- terminal blocking group of NADH-cytochrome b5 reductase as myristic acid and the complete amino acid sequence of the membrane-binding domain, J. Biol. Chem, vol.259, pp.13349-13354, 1984. ,
Gastric lipolysis of maternal milk triglycerides, gastric absorption of medium chain fatty acids in the young rabbit (author's transl), J. Physiol. (Paris), vol.76, pp.159-166, 1980. ,
M??tabolisme et fonctions de l???acide myristique, Ol??agineux, Corps gras, Lipides, vol.8, issue.2, pp.161-166, 2001. ,
DOI : 10.1051/ocl.2001.0161
Exogenous myristic acid acylates proteins in cultured rat hepatocytes, The Journal of Nutritional Biochemistry, vol.13, issue.2, pp.66-74, 2002. ,
DOI : 10.1016/S0955-2863(01)00196-6
Although it is rapidly metabolized in cultured rat hepatocytes, lauric acid is used for protein acylation, Reproduction Nutrition Development, vol.43, issue.5, pp.419-430, 2003. ,
DOI : 10.1051/rnd:2003036
URL : https://hal.archives-ouvertes.fr/hal-00900517
Dietary myristic acid at physiologically relevant levels increases the tissue content of C20:5 n-3
and C20:3 n-6 in the rat, Reproduction Nutrition Development, vol.45, issue.5, pp.599-612, 2005. ,
DOI : 10.1051/rnd:2005048
URL : https://hal.archives-ouvertes.fr/hal-00900585
Identification and characterization of recombinant and native rat myristoyl-CoA: protein N-myristoyltransferases, Molecular and Cellular Biochemistry, vol.10, issue.R21, pp.161-170, 2006. ,
DOI : 10.1007/s11010-005-9108-0
In rat hepatocytes, myristic acid occurs through lipogenesis, palmitic acid shortening and lauric acid elongation, animal, vol.6, issue.06, pp.820-826, 2007. ,
DOI : 10.1083/jcb.113.6.1313
Substitution of dietary oleic acid for myristic acid increases the tissue storage of ??-linolenic acid and the concentration of docosahexaenoic acid in the brain, red blood cells and plasma in the rat, animal, vol.78, issue.04, pp.636-644, 2008. ,
DOI : 10.1051/rnd:2004020
URL : https://hal.archives-ouvertes.fr/hal-00729914
Regulation of mammalian desaturases by myristic acid: N-terminal myristoylation and other modulations, Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, vol.1811, issue.1, pp.1-8, 2011. ,
DOI : 10.1016/j.bbalip.2010.09.005
URL : https://hal.archives-ouvertes.fr/hal-00730171
Characterization of Type I and Type II Myristoyl-CoA:protein N -Myristoyltransferases with the Acyl-CoAs found on Heterogeneously Acylated Retinal Proteins, Experimental Eye Research, vol.75, issue.1, pp.87-97, 2002. ,
DOI : 10.1006/exer.2002.1189
-Myristoyltransferase 2 expression in human colon cancer: Cross-talk between the calpain and caspase system, FEBS Letters, vol.356, issue.8, pp.2021-2026, 2006. ,
DOI : 10.1016/j.febslet.2006.02.076
URL : https://hal.archives-ouvertes.fr/hal-00145802
On the question of half-or fullsite reactivity of animal fatty acid synthetase, J. Biol. Chem, vol.259, pp.3605-3611, 1984. ,
Ceramide Channels Increase the Permeability of the Mitochondrial Outer Membrane to Small Proteins, Journal of Biological Chemistry, vol.277, issue.30, pp.26796-26803, 2002. ,
DOI : 10.1074/jbc.M200754200
Studies on fat digestion, absorption, and transport in the suckling rat. II. Triacylglycerols: molecular species, stereospecific analysis, and specificity of hydrolysis by lingual lipase, J. Lipid Res, vol.22, pp.675-679, 1981. ,
Interaction of non-myristoylated NADH-cytochrome b5 reductase with cytochrome b5-dimyristoylphosphatidylcholine vesicles, J. Biol. Chem, vol.268, pp.23168-23171, 1993. ,
Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans, Nature Communications, vol.789, 2013. ,
DOI : 10.1038/35038090
Ghrelin O-Acyltransferase Assays and Inhibition, Methods Enzymol, vol.514, pp.205-228, 2012. ,
DOI : 10.1016/B978-0-12-381272-8.00013-1
Architectural Organization of the Metabolic Regulatory Enzyme Ghrelin O-Acyltransferase, Journal of Biological Chemistry, vol.288, issue.45, pp.32211-32228, 2013. ,
DOI : 10.1074/jbc.M113.510313
Identification and Characterization of a Sphingolipid Delta 4-Desaturase Family, Journal of Biological Chemistry, vol.277, issue.28, pp.25512-25518, 2002. ,
DOI : 10.1074/jbc.M202947200
Global profiling of co- and post-translationally N-myristoylated proteomes in human cells, Nature Communications, vol.336, 2014. ,
DOI : 10.1038/ncomms5919
The Biology and Enzymology of Eukaryotic Protein Acylation, Annual Review of Biochemistry, vol.57, issue.1, pp.69-99, 1988. ,
DOI : 10.1146/annurev.bi.57.070188.000441
Ghrelin induces adiposity in rodents, Nature, vol.407, issue.6806, pp.908-913, 2000. ,
DOI : 10.1038/35038090
Fatty acid composition of adipose tissue and serum lipids are valid biological markers of dairy fat intake in men, J. Nutr, vol.131, pp.828-833, 2001. ,
N-Myristoyltransferase 1 Is Essential in Early Mouse Development, Journal of Biological Chemistry, vol.280, issue.19, pp.18990-18995, 2005. ,
DOI : 10.1074/jbc.M412917200
Obestatin, a Peptide Encoded by the Ghrelin Gene, Opposes Ghrelin's Effects on Food Intake, Science, vol.310, issue.5750, pp.996-999, 2005. ,
DOI : 10.1126/science.1117255