Impact of n-3 Docosapentaenoic Acid Supplementation on Fatty Acid Composition in Rat Differs Depending upon Tissues and Is Influenced by the Presence of Dairy Lipids in the Diet

Gaëtan Drouin 1 Étienne Guillocheau 1 Daniel Catheline 1 Charlotte Baudry 2 Pascale Le Ruyet 2 Vincent Rioux 1 Philippe Legrand 1
1 Laboratoire de Biochimie et Nutrition Humaine
2 Groupe Lactalis
Abstract : The n-3 docosapentaenoic acid (n-3 DPA) could be a novel source of n-3 long-chain polyunsaturated fatty acids (LCPUFA) with beneficial physiological effects. Following the supplementation of 0.5% purified n-3 DPA for 3 weeks from weaning, the n-3 DPA content increased in one-half of the 18 studied tissues (from +50% to +110%, p < 0.05) and mostly affected the spleen, lung, heart, liver, and bone marrow. The n-3 DPA was slightly converted into DHA (+20% in affected tissues, p < 0.05) and mostly retroconverted into EPA (35–46% of n-3 DPA intake in liver and kidney) showing an increased content of these LCPUFA in specific tissues. The partial incorporation of dairy lipids in the diet for 6 weeks increased overall n-3 PUFA status and brain DHA status. Furthermore, the n-3 DPA supplementation and dairy lipids had an additive effect on the increase of n-3 PUFA tissue contents. Moreover, n-3 DPA supplementation decreased plasma cholesterol.
Keywords : tissue composition eicosapentaenoic acid (EPA) dairy lipids cholesterol polyunsaturated fatty acid (PUFA) metabolism
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Gaëtan Drouin, Étienne Guillocheau, Daniel Catheline, Charlotte Baudry, Pascale Le Ruyet, et al.. Impact of n-3 Docosapentaenoic Acid Supplementation on Fatty Acid Composition in Rat Differs Depending upon Tissues and Is Influenced by the Presence of Dairy Lipids in the Diet. Journal of Agricultural and Food Chemistry, American Chemical Society, 2018, 66 (38), pp.9976 - 9988. ⟨10.1021/acs.jafc.8b03069⟩. ⟨hal-01884792⟩

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