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Journal articles
Interactive effects of maternal and weaning high linoleic acid intake on hepatic lipid metabolism, oxylipins profile and hepatic steatosis in offspring
Abstract : Non-alcoholic fatty liver disease (NAFLD) has been described as a hepatic manifestation of the metabolic syndrome. When several studies correlated maternal linoleic acid (LA) intake with the development of obesity, only few links have been made between n-6 fatty acid (FA) and NAFLD. Herein, we investigated the influence of both maternal and weaning high LA intake on lipid metabolism and susceptibility to develop later metabolic diseases in offspring. Pregnant rats were fed a control-diet (2% LA) or a LA-rich diet (l2% LA) during gestation and lactation. At weaning, offspring was assigned to one of the two diets, i.e. either maintained on the same maternal diet or fed the other diet for six months. Physiological, biochemical parameters and hepatic FA metabolism were analyzed. We demonstrated that the interaction between the maternal and weaning LA intake altered metabolism in offspring and could lead to hepatic steatosis. This phenotype was associated with altered hepatic FA content and lipid metabolism. Interaction between maternal and weaning LA intake led to a specific pattern of n-6 and n-3 oxylipins that could participate to the development of hepatic steatosis in offspring. Our findings highlight the significant interaction between maternal and weaning high LA intake to predispose offspring to later metabolic disease and support the predictive adaptive response hypothesis.
Cited literature [71 references]
https://hal-agrocampus-ouest.archives-ouvertes.fr/hal-02349325
Contributor : Catherine Cliquet Connect in order to contact the contributor
Submitted on : Monday, December 16, 2019 - 4:53:07 PM
Last modification on : Friday, July 30, 2021 - 5:21:56 PM
Long-term archiving on: : Tuesday, March 17, 2020 - 7:47:27 PM
Contributor : Catherine Cliquet Connect in order to contact the contributor
Submitted on : Monday, December 16, 2019 - 4:53:07 PM
Last modification on : Friday, July 30, 2021 - 5:21:56 PM
Long-term archiving on: : Tuesday, March 17, 2020 - 7:47:27 PM